The lab's main inspiration is evolution, which is not only beautiful and surprising but also useful and relevant; specifically, we focus on the coevolution of structure and function, which we are currently exploring in cancer.

Cutting-edge genomics technologies play a big role in our research. For example, we are currently making extensive use of 10X Technology's read clouds and Oxford Nanopore's long reads to perform better phasing and assembly of cancer and normal genomes.

We develop lab protocols as well as computational approaches for these new technologies. Much of our research is collaborative with other groups on campus and elsewhere.


Aneuploidy evolution of Patient 6. See Newburger et al, Genome Research 2013

Aneuploidy evolution of Patient 6. See Newburger et al, Genome Research 2013