The lab's main inspiration is evolution, which is not only beautiful and surprising but also useful and relevant. Specifically, we focus on the evolution of function, which we are currently exploring in cancer.

We have several cancer evolution projects ongoing in which we explore the relationship between structural and functional evolution of the cancer genome.

Cutting-edge genomics technologies play a big role in our research. For example, we are currently making extensive use of 10X Technology's read clouds to perform better phasing and structural variant calling in cancer genomes. Similarly, we are beginning to use Oxford Nanopore's long reads for genome assembly. We develop lab protocols as well as computational approaches for these new technologies.

Much of our research is collaborative with other groups on campus and elsewhere.


Aneuploidy evolution of Patient 6. See Newburger et al, Genome Research 2013

Aneuploidy evolution of Patient 6. See Newburger et al, Genome Research 2013